The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Safety of 5-Bromopyrimidine.
Gisbertz, Sebastian;Reischauer, Susanne;Pieber, Bartholomaeus research published 《 Overcoming limitations in dual photoredox/nickel-catalyzed C-N cross-couplings due to catalyst deactivation》, the research content is summarized as follows. Dual photoredox/nickel-catalyzed C-N cross-couplings suffer from low yields for electron-rich aryl halides. The formation of catalytically inactive nickel-black is responsible for this limitation and causes severe reproducibility issues. Here, that catalyst deactivation was avoided by using a carbon nitride photocatalyst were demonstrated. The broad absorption of the heterogeneous photocatalyst enabled wavelength-dependent control of the rate of reductive elimination to prevent nickel-black formation during the coupling of cyclic, secondary amines and aryl halides. A second approach, which was applicable to a broader set of electron-rich aryl halides, was to run the reactions at high concentrations to increase the rate of oxidative addition Less nucleophilic, primary amines was coupled with electron-rich aryl halides by stabilizing low-valent nickel intermediates with a suitable additive. The developed protocols enabled reproducible, selective C-N cross-couplings of electron-rich aryl bromides and also applied for electron-poor aryl chlorides.
Safety of 5-Bromopyrimidine, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia