On July 17, 2020, Gong, Yong; Chen, Lu; Zhang, Wei; Salter, Rhys published an article.Application In Synthesis of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione The title of the article was Transglycosylation in the Modification and Isotope Labeling of Pyrimidine Nucleosides. And the article contained the following:
Transglycosylation of pyrimidine nucleosides is demonstrated in a one-pot synthesis of uridine derivatives under microwave irradiation Inductive activation of 2′,3′,5′-tri-O-acetyl uridine with a 5-nitro group produces a more-reactive glycosyl donor. Under optimized Vorbruggen conditions, the 5-nitrouridine facilitates a reversible nucleobase exchange with a series of 5-substituted uracils. The protocol is also exemplified in a gram-scale reaction under thermal heating. The strategy provides easy access to isotopically labeled uridine. The experimental process involved the reaction of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione(cas: 4433-40-3).Application In Synthesis of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
The Article related to vorbruggen nitrouridine nucleobase thermal heating microwave transglycosylation nucleoside, transglycosylation pyrimidine nucleoside isotope labeling synthesis microwave irradiation and other aspects.Application In Synthesis of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia