Microwave-expedited one-pot, two-component, solvent-free synthesis of functionalized pyrimidines was written by Goswami, Shyamaprosad;Jana, Subrata;Dey, Swapan;Adak, Avijit Kumar. And the article was included in Australian Journal of Chemistry in 2007.Electric Literature of C16H13N3 This article mentions the following:
The synthesis of a series of diversely substituted pyrimidines under solvent-free conditions in good yields is described. Under microwave irradiation, a variety of nucleophilic substrates containing the N-C-N unit with β-dicarbonyl compounds, Et cyanoacetate, malononitrile, and chalcones was cyclized to give pyrimidines. A combinatorial type approach for a one-step synthesis was developed where a ring-closing condensation is followed by spontaneous aromatization to afford 28 functionalized and aryl/alkyl-substituted pyrimidines. In the experiment, the researchers used many compounds, for example, 4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8Electric Literature of C16H13N3).
4,6-Diphenylpyrimidin-2-amine (cas: 40230-24-8) belongs to pyrimidine derivatives. Pyrimidines are isomeric with two other forms of diazines: pyridazine, with the nitrogen atoms in the 1 and 2 positions; and pyrazine, with the nitrogen atoms in the 1 and 4 positions. Drugs having the pyrimidine motif have manifested to exhibit gratifying biological activity like anticancer, antiviral, anti-inflammatory, antibacterial, and antihypertensive activities.Electric Literature of C16H13N3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia