Incorporation of metabolites of 2′-fluoro-5-iodo-1-β-D-arabinofuranosylcytosine into deoxyribonucleic acid of neoplastic and normal mammalian tissues was written by Grant, Alan J.; Feinberg, Aaron; Chou, Ting-Chao; Watanabe, Kyoichi A.; Fox, Jack J.; Philips, Frederick S.. And the article was included in Biochemical Pharmacology on March 15,1982.Reference of 56632-83-8 The following contents are mentioned in the article:
Following treatment of mice with 2-14C-labeled 2′-fluoro-5-iodo-1-β-D-arabinofuranosylcytosine (I) [69123-90-6], a new and potent antiherpetic agent, enzyme degradation of highly purified DNA from the small intestine and anal. of the resulting nucleosides failed to reveal the presence of unchanged I. Three metabolites were found, namely the 2′-fluoro-1-β-D-arabinofuranosyl nucleosides of cytosine, thymine, and 5-iodouracil. Labeled metabolites of I were also found in the DNA isolated from P815 leukemia cells of mice given I-2-14C. These metabolites are also potent antiherpetic agents. This study involved multiple reactions and reactants, such as 4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8Reference of 56632-83-8).
4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 56632-83-8) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Reference of 56632-83-8
56632-83-8;4-Amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;The future of 56632-83-8;New trend of C9H12FN3O4;function of 56632-83-8