Grey, Daphne; Hamilton-Miller, J. M. T. published an article in 1977, the title of the article was Sensitivity of Pseudomonas aeruginosa to sulfonamides and trimethoprim and the activity of the combination trimethoprim: sulfamethoxazole.Computed Properties of 23256-42-0 And the article contains the following content:
P. aeruginosa strains from urinary infections were resistant or only moderately sensitive to sulfadiazine [68-35-9], sulfamethoxazole (I) [723-46-6], sulfadimidine [57-68-1], or trimethoprim lactate (II lactate) [23256-42-0], but a marked synergy between I and II was noted with the moderately sensitive strains. Thus, therapeutically attainable urinary levels of these drugs (which were ineffective individually) were quite inhibitory to P. aeruginosa when used in combination. The min. inhibitory concentrations of I and II when used in combination suggested that disks containing I and II at a 1:2 ratio would be more appropriate for determining the drug susceptibility of urinary pathogens than the usual 1:20 ratio. The experimental process involved the reaction of 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate(cas: 23256-42-0).Computed Properties of 23256-42-0
The Article related to sulfonamide trimethoprim pseudomonas sensitivity, urine pseudomonas trimethoprim sulfamethoxazole, Biochemical Interactions: Microbial Systems and other aspects.Computed Properties of 23256-42-0
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia