Guan, Aiying; Wang, Mingan; Yang, Jinlong; Wang, Lizeng; Xie, Yong; Lan, Jie; Liu, Changling published the artcile< Discovery of a New Fungicide Candidate through Lead Optimization of Pyrimidinamine Derivatives and Its Activity against Cucumber Downy Mildew>, Formula: C5H4Cl2N2O, the main research area is fungicide pyrimidinamine derivative preparation lead optimization cucumber downy mildew; development of resistance; downy mildew; pyrimidinamine fungicide candidate; unique mode of action.
Downy mildew is one of the most highly destructive of the diseases that cause damage to fruits and vegetables. Because of the continual development of resistance, it is important to discover new fungicides with different modes of action from existing fungicides for the control of downy mildew. This study is a continuation of our previous work on the novel pyrimidinamine lead compound, (I), and includes field trials for the identification of the optimal candidate. A new compound, 5-Chloro-N-(2-(6-(4-chlorophenoxy)pyridin-3yl)ethyl)-6-(difluoromethyl)pyrimidin-4-amine, (II), was obtained from 4,5-Dichloro-6-(difluoromethyl)pyrimidine and 2-(6-(4-chlorophenoxy)pyridin-3-yl)ethanamine, which gave a lower EC50 value (0.10 mg/L) against downy mildew than lead compound I (0.19 mg/L) and the com. fungicides diflumetorim, dimethomorph, and cyazofamid (1.01-23.06 mg/L). Compound II displayed similar broad-spectrum fungicidal activity to compound I but better field efficacy than compound I, cyazofamid, and flumorph. The present work indicates that pyrimidinamine compound II is a candidate for further development as a com. fungicide for the control of downy mildew.
Journal of Agricultural and Food Chemistry published new progress about Agrochemical fungicides. 5018-38-2 belongs to class pyrimidines, and the molecular formula is C5H4Cl2N2O, Formula: C5H4Cl2N2O.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia