An alternative preparation of the 2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane salt from phosphonoacetic acids and some applications in heterocyclic synthesis was written by Gupton, John T.;Gall, John E.;Riesinger, Steve W.;Smith, Stanton Q.;Bevirt, Kathy M.;Sikorski, James A.;Dahl, Maria L.;Arnold, Zdenek. And the article was included in Journal of Heterocyclic Chemistry in 1991.Safety of 2-Methoxypyrimidine-5-carbaldehyde This article mentions the following:
An alternative preparation of Me2N+:CHCR:CHNMe2 . n ClO4– (I; R = CHN+Me2; n = 2) from phosphonoacetic acid is described along with its application to the synthesis of 5-formylpyrimidines, e.g., II (R1 = Me, OMe, SMe, NH2, NMe2, NHEt, Ph) and masked 4-formylpyrazoles III (Ar = substituted Ph) via cyclization with RC(NH2):NH or ArNHNH2, resp. I (R = H; n = 1), thought to be an intermediate in the preparation of I (R = CHN+Me2; n = 2) was also isolated. In the experiment, the researchers used many compounds, for example, 2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1Safety of 2-Methoxypyrimidine-5-carbaldehyde).
2-Methoxypyrimidine-5-carbaldehyde (cas: 90905-32-1) belongs to pyrimidine derivatives. The pyrimidine derivatives can easily interact with enzymes, genetic materials, and bio components within the cell. For example, the neurotoxin tetrodotoxin is a pyrimidine derivative. It is found in a number of species including the Japanese puffer fish, the blue-ringed octopus, and the orange-bellied newt. Tetrodotoxin prevents the transmission of nerve signals and can result in paralysis and death.Safety of 2-Methoxypyrimidine-5-carbaldehyde
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia