On March 29, 2007, Han, Cheol Kyu; Yoon, Jeonghyeok; Kim, Nam-Doo; Kim, Jin-Ah published a patent.SDS of cas: 42518-42-3 The title of the patent was Preparation of 5,6-dimethylthieno[2,3-d]pyrimidine derivatives as antiviral agents. And the patent contained the following:
Title compounds represented by the formula I [wherein R1 = 4-morpholinophenyl or 6-morpholinopyridin-3-yl; R2 = 2-, 3- or 4-pyridinyl; and pharmaceutically acceptable salts thereof] were prepared as antiviral agents. For example, reaction of 2,4-dichloro-5,6-dimethylthieno[2,3-d]pyrimidine with 4-(morpholino)aniline (quant.), and followed by reaction with piperazine (15%) and picolinoyl chloride hydrochloride (30%), gave I (R1 = 4-morpholinophenyl, R2 = 2-pyridinyl). The title compounds I showed HCV replicon inhibitory activity with EC50 values of 0.45 – 0.71 μM, and low cytotoxicity. Thus, I and their pharmaceutical compositions are useful for the treatment of hepatitis C. The experimental process involved the reaction of 2,4-Dichloro-5,6-dimethylthieno[2,3-d]pyrimidine(cas: 42518-42-3).SDS of cas: 42518-42-3
The Article related to dimethylthienopyrimidine morpholinophenyl preparation hcv inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 42518-42-3
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia