Han, Shuwen; Zhuang, Chunlin; Zhou, Wei; Chen, Fener published an article in 2021. The article was titled 《Structural-based optimizations of the marine-originated meridianin C as glucose uptake agents by inhibiting GSK-3β》, and you may find the article in Marine Drugs.COA of Formula: C4H2Cl2N2 The information in the text is summarized as follows:
Glycogen synthase kinase 3β (GSK-3β) is a widely investigated mol. target for numerous diseases, and inhibition of GSK-3β activity has become an attractive approach for the treatment of diabetes. Meridianin C, an indole-based natural product isolated from marine Aplidium meridianum, has been reported as a potent GSK-3β inhibitor. In the present study, applying the structural-based optimization strategy, the pyrimidine group of meridianin C was modified by introducing different substituents based on the 2-aminopyrimidines-substituted pyrazolo pyridazine scaffold. Among them, compounds B29 and B30 showed a much higher glucose uptake than meridianin C (<5%) and the pos. compound 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8, 16%), with no significant toxicity against HepG2 cells at the same time. Furthermore, they displayed good GSK-3β inhibitory activities (IC 50 = 5.85; 24.4 μM). These results suggest that these meridianin C analogs represent novel lead compounds with therapeutic potential for diabetes.2,4-Dichloropyrimidine(cas: 3934-20-1COA of Formula: C4H2Cl2N2) was used in this study.
2,4-Dichloropyrimidine(cas: 3934-20-1) is a member of organic chlorides. Organic chloride content in crude oil can be detected through specialized laboratory analysis. Care and attention are essential while sampling and testing.COA of Formula: C4H2Cl2N2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia