Hansen, Steen Uldall;Bols, Mikael published 《1-Azaribofuranoside analogs as designed inhibitors of purine nucleoside phosphorylase. Synthesis and biological evaluation》. The research results were published in《Acta Chemica Scandinavica》 in 1998.Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione The article conveys some information:
Pyrrolidine analogs of 2-deoxyribofuranose, having nitrogen in place of anomeric carbon, have been synthesized as potential transition state analogs of enzymic nucleoside cleavage. Efficient synthetic methods were developed that allowed the synthesis of a wide range of 4-substituted 3-hydroxypyrrolidines starting from pyrroline and using opening of the pyrrolidine 3,4-epoxide with carbon nucleophiles. Among the compounds synthesized were the 4-cyano-, 4-hydroxymethyl and 4-carboxymethyl derivatives From the hydroxymethyl derivative, N-alkylation with chloromethyluracil gave an inosine analog. The new compounds were tested for inhibition of human erythrocyte purine nucleoside phosphorylase. Furthermore, a solid-phase synthesis of 1′-azanucleoside analogs was developed.6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7) were involved in the experimental procedure.
6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione (cas: 18592-13-7 Name: 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione) was used in the synthesis of: 5-bromo-6-(chloromethyl)uracil, pteridine compounds, potential anticancer agents, substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia