Identification of disulfiram as a potential antifungal drug by screening small molecular libraries was written by Hao, Weifeng;Qiao, Dan;Han, Ying;Du, Ning;Li, Xuefen;Fan, Yufeng;Ge, Xuejun;Zhang, Heyu. And the article was included in Journal of Infection and Chemotherapy in 2021.Computed Properties of C24H27N5O2 The following contents are mentioned in the article:
Candida albicans and Candida auris strains are common causative species of Candidiasis. The limited number of antifungal drugs and the current situation of resistance to existing antifungals force us to search for new antifungal alternatives. In this work, primary screening of small mol. libraries (Metabolism Compound Library and Epigenetics Compound Library) consisting of 584 compounds against Candida albicans SC5314 was performed. The dose-response assays, XTT assays, SEM and confocal laser scanning microscopy were used to confirm the antifungal activities of the selected compounds against Candida strains. Through the primary screening, we identified five compounds (U73122, disulfiram, BSK805, BIX01294, and GSKJ4) that inhibited strains growth ≥ 80% for dose-response assays. Disulfiram was identified as the most potent repositionable antifungal drug with 50% growth inhibition detected at a concentration as low as 1 mg/L. The further results showed the antifungal activity of disulfiram against biofilm formation of Candida strains with a 50% min. inhibitory concentration ranging from 32 to 128 mg/L. Further observations by SEM and confocal laser scanning microscopy confirmed the destruction of biofilm architecture and the change of biofilm morphol. after being exposed to disulfiram. The study indicated the potential clin. application of disulfiram as a promising antifungal drug against candidiasis. This study involved multiple reactions and reactants, such as Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate (cas: 1373423-53-0Computed Properties of C24H27N5O2).
Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate (cas: 1373423-53-0) belongs to pyrimidine derivatives. Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Computed Properties of C24H27N5O2
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia