Hasegawa, Tetsuya; Seki, Toshinobu; Juni, Kazuhiko; Saneyoshi, Mineo; Kawaguchi, Takeo published their research in Journal of Pharmaceutical Sciences on December 31 ,1993. The article was titled 《Prodrugs of 2′,3′-didehydro-3′-deoxythymidine》.Recommanded Product: 122567-97-9 The article contains the following contents:
Six ester prodrugs of 2′,3′-didehydro-3′-deoxythymidine (I) were prepared, and their physicochem. properties evaluated. Marked differences were observed All of the prodrugs were chem. stable within the pH range 2-7. Hydrolysis of these esters was observed in all cases for 4 rat enzyme systems (plasma, liver, duodenum, and kidney), with I being regenerated. I or the prodrug was administered orally to rats, and the plasma concentrations of I and a corresponding prodrug were measured. The half-life of I after i.v. administration was 35.9 min. The half-life calculated from the terminal phase and the maximum concentration in plasma following oral administration of I were 35.9 min and 48.4 μM, resp. After oral prodrug administration (with water or olive oil as a solvent), though none of the prodrugs was detected in plasma except for 5′-hemisuccinyl derivative of I and 5′-hemiglutaryl derivative of I with olive oil as a solvent, retention time of plasma I concentration was extended and the elevated I concentration in plasma decreased.((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9Recommanded Product: 122567-97-9) was used in this study.
((2S,5R)-5-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl)methyl benzoate(cas: 122567-97-9) belongs to pyrimidine. Pyrimidine nucleotide derivatives have a wide range of biological applications. For example, pyrimidine derivatives are useful in DNA repair studies involving cancer and epigenetics.Recommanded Product: 122567-97-9
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia