Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains was written by Hay, Duncan A.;Rogers, Catherine M.;Fedorov, Oleg;Tallant, Cynthia;Martin, Sarah;Monteiro, Octovia P.;Muller, Susanne;Knapp, Stefan;Schofield, Christopher J.;Brennan, Paul E.. And the article was included in MedChemComm in 2015.Category: pyrimidines This article mentions the following:
Emerging evidence suggests bromodomain-containing proteins 7 and 9 (BRD7 and BRD9) have roles in the regulation of human transcription and disease including cancer. We describe potent and selective inhibitors of the BRD7 and BRD9 bromodomains intended for use as tools to elucidate the biol. roles of BRD7 and BRD9 in healthy and diseased cells. In the experiment, the researchers used many compounds, for example, 2-Ethynylpyrimidine (cas: 37972-24-0Category: pyrimidines).
2-Ethynylpyrimidine (cas: 37972-24-0) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Pyrimidine derivatives also play an important role in drug development, either in concert with other compounds or on their own.Category: pyrimidines
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia