Hirai, Eizo published the artcileBehavior of 4-amino-5-carboxy-2-methylpyrimidine in aqueous solution, Safety of Ethyl 4-amino-2-methylpyrimidine-5-carboxylate, the main research area is .
cf. CA 64, 17396e. MeI (4 ml.) added to 1 g. 4-amino-5-ethoxycarbonyl-2-methylpyrimidine in 10 ml. Me2CO, the mixture refluxed 1 hr., and the precipitate formed on cooling heated 1 hr. on a steam bath with 10 ml. 5% HI gave 0.6 g. hemihydrate of the 1-methyl betaine of 4-amino-5-carboxy-2-methylpyrimidine, decomposed 226-7° (aqueous alc.). The 1-methyl betaine of 2-aminonicotinic acid, decomposed 269-71°, and the 1-methyl betaine of 2-aminoisonicotinic acid were similarly prepared The basic ionization constants of 2-aminonicotinic acid (I) and 2-aminoisonicotinic acid (II) and of their Me and Et esters and 1-methyl betaines, and of 4-amino-5-carboxy-2-methylpyrimidine (III) and its Et ester and 1-methyl betaine were determined potentiometrically and spectrophotometrically. The basic pKa values of I and II were much lower than those calculated from the Hammett eq. I and II exist largely as zwitterions in H2O. On the basis of the uv absorption spectra of I-III as compared with those of the corresponding Et esters and 1-methyl betaines, I-III exist predominantly as zwitterions in H2O. An evaluation of the equilibrium constants between the zwitterion form and uncharged form in H2O for I and III from the Edsall and Blanchard equation (CA 27, 5233) is in agreement with this conclusion. Ir spectra of I-III in the solid state show that the compounds form an uncharged polymer linked by H bonding between the carboxyl and a nuclear N.
Chemical & Pharmaceutical Bulletin published new progress about Ionization. 5472-46-8 belongs to class pyrimidines, name is Ethyl 4-amino-2-methylpyrimidine-5-carboxylate, and the molecular formula is C8H11N3O2, Safety of Ethyl 4-amino-2-methylpyrimidine-5-carboxylate.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia