Hornillo-Araujo, Ana R.; Burrell, Adam J. M.; Aiertza, Miren K.; Shibata, Takayuki; Hammond, David M.; Edmont, Dolores; Adams, Harry; Margison, Geoffrey P.; Williams, David M. published the artcile< The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine>, Formula: C7H8N4O, the main research area is tricyclic pyrrolopyrimidine analog thioguanine methylguanine preparation; thiopyran tricyclic pyrrolopyrimidine analog thioguanine methylguanine preparation; thiepane tricyclic pyrrolopyrimidine analog thioguanine methylguanine preparation; DNA cross linking tricyclic pyrrolopyrimidine analog thioguanine methylguanine preparation; oligonucleotide pseudosubstrate DNA linking tricyclic pyrrolopyrimidine analog thioguanine methylguanine.
The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogs of S6-methylthioguanine are described. The crystal structures and pKa values of these and related O6-methylguanine analogs are reported. All compounds display higher pKa values than O6-methylguanine with the sulfur-containing analogs being the more basic and exhibiting higher stability in aqueous solution In a standard substrate assay with the human repair protein O6-methylguanine-DNA methyltransferase (MGMT) only the oxygen-containing analog displayed activity.
Organic & Biomolecular Chemistry published new progress about Crystal structure. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Formula: C7H8N4O.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia