Huan, Xiang team published research in European Journal of Medicinal Chemistry in 2022 | 1722-12-9

Computed Properties of 1722-12-9, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., 1722-12-9.

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Computed Properties of 1722-12-9.

Huan, Xiang;Wang, Yanhui;Peng, Xiaofeng;Xie, Shanshan;He, Qian;Zhang, Xiaofei;Lan, Lefu;Yang, Chunhao research published ã€?Design, synthesis and biological evaluations of substituted pyrazoles as pyrrolomycin analogues against staphylococcal biofilmã€? the research content is summarized as follows. Designed and synthesized two series of substituted pyrazoles I [R = 4,5-di-F, 4-F,5-Cl, 4,5-di-Cl, 4-F,5-Me, 3,5-di-F; R1 = CF3, CN] and II [R1 = H, CF3, CN, COOH, CO2Me, C(O)NH2; R2 = H, 5,7-di-Cl,8-MeO, 5,7-di-Cl,8-OH; X = O, S, SO2] as pyrrolomycin analogs. Compounds I [R = 4-F,5-Cl, 4,5-di-Cl; R1 = CF3, CtN] displayed potent antibacterial activity against various vancomycin-resistant Enterococcus fecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA), and compound I [R = 4,5-di-Cl; R1 = CF3] showed the most potent activity against MRSA (MIC = 0.0625μg/mL), vancomycin-intermediate Staphylococcus aureus (VISA) (MIC = 0.0313μg/mL). Further study indicated that compound I [R = 4,5-di-Cl; R1 = CN] could significantly reduce the biofilm formation of MRSA and exhibited promising selectivity. In vitro liver microsomal stability was also evaluated and the results manifested that compound I [R = 4,5-di-Cl; R1 = CN] was metabolically stable in human liver microsomes.

Computed Properties of 1722-12-9, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., 1722-12-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia