Hwang, Long-Chih; Wang, Eng-Chi; Lee, Kuan-Han; Tzeng, Cherng-Chyi published the artcile< Synthetic and antiviral studies on certain acyclo-nucleosides of 5-substituted 6-azauracils>, Name: 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione, the main research area is azauracil acyclic nucleoside antitumor antiviral; acyclic nucleoside preparation antitumor antiviral.
In view of the unique biol. properties and chemotherapeutic activities exhibited by DHPG and 6-azauridine, we initiated the present study to explore new acyclic nucleosides in which acyclic residues were attached to 6-azauracil and its derivatives by a glycosidic linkage in an attempt to search for more potent antiviral and/or antitumor agents. Coupling of persilylated intermediates of 5-substituted 6-azauracils with 1,3-dibenzyloxy-2-chloromethoxypropane, 1-benzyloxy-3-bromo-2-chloromethoxypropane, and 1-benzyloxy-2-chloromethoxybutane, resp., afforded three new series of protected acyclic nucleosides which were deprotected to give 5-substituted 6-azauracil acyclo-nucleosides, e.g. I (R = H, Br, R1 = OH, Me). None of the compounds exhibited significant antiviral activities against herpes simplex viruses types 1 and 2.
Chinese Pharmaceutical Journal (Taipei, Taiwan) published new progress about Antitumor agents. 4956-05-2 belongs to class pyrimidines, and the molecular formula is C3H2BrN3O2, Name: 6-Bromo-1,2,4-triazine-3,5(2H,4H)-dione.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia