In 2019,CrystEngComm included an article by Hyodo, Tadashi; Kawahata, Masatoshi; Hikami, Yuya; Komatsu, Ai; Tominaga, Masahide; Yamaguchi, Kentaro. Reference of 4,6-Dichloropyrimidine. The article was titled 《Cycloalkanes and cycloalkenes in dispersive force oriented inclusion crystals by a functionalized acyclic host molecule》. The information in the text is summarized as follows:
A disubstituted adamantane derivative bearing chloropyrimidine units (1) was synthesized as an acyclic host mol. to construct guest-inclusion crystalline materials, and the mol. structures of these crystalline materials were determined by X-ray crystallog. anal. The crystallization of 1 and trans-decahydronaphthalene (a) in chloroform afforded co-crystal (1a) with 2 : 1 host : guest complexation stoichiometry. The guest mol. was accommodated within the cavity of the cyclic dimers of 1 built from Cl···π interactions between the chloropyrimidine units. These complexes were assembled into network structures through intermol. interactions. From the Hirshfeld surface anal. and the 2D fingerprint plot of a in co-crystal 1a, the maximum contribution is from the H···H contacts between 1 and a, indicating that the main driving force for the guest inclusion is dispersive force. Co-crystals containing cycloalkanes and cycloalkenes (b-f) and having the same stoichiometry were obtained under identical conditions. In all the co-crystals, the shapes and sizes of the cyclic dimers and the mol. networks were similar to those of crystal 1a, and the mol. structures of the guests were characterized. In addition to this study using 4,6-Dichloropyrimidine, there are many other studies that have used 4,6-Dichloropyrimidine(cas: 1193-21-1Reference of 4,6-Dichloropyrimidine) was used in this study.
4,6-Dichloropyrimidine(cas: 1193-21-1) is a member of organic chlorides. Almost all organochlorine compounds are synthesized. It is widely used as intermediates, solvents and pesticides of chemical synthetic products.Reference of 4,6-Dichloropyrimidine
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia