Comparison of antiviral effects of mismatched double-stranded RNA and 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyl-uracil (D-FMAU) against duck hepatitis B virus in vitro was written by Ijichi, K.; Ida, S.; Machida, H.; Shimada, K.. And the article was included in Antiviral Chemistry & Chemotherapy on November 30,1997.COA of Formula: C10H13FN2O5 The following contents are mentioned in the article:
The effects of mismatched double-stranded RNA (mdsRNA) and 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-methyl-uracil (D-FMAU) on the replication of duck hepatitis B virus (DHBV) were examined in duck primary hepatocytes infected with DHBV. The 50% inhibitory doses of m-dsRNA and D-FMAU for the replication of DHBV DNA were 0.34±0.06 and 0.007±0.001 μg mL-1, resp. Mismatched dsRNA slightly inhibited the intermediate DHBV DNA at a concentration as high as 1.0 μg mL-1, whereas the DHBV replicative form was markedly suppressed in the presence of 0.1 μg mL-1 of D-FMAU. On the other hand, m-dsRNA inhibited DHBV DNA replication even after the compound was removed from the culture medium, while the efficacy of D-FMAU did not persist after the cessation of treatment. The anal. of DHBV RNA revealed that m-dsRNA markedly inhibited DHBV RNA transcription, while D-FMAU only marginally suppressed the transcription of viral RNA. These results indicate that m-dsRNA inhibits DHBV RNA transcription rather than DHBV DNA replication and that this suppression of DHBV RNA transcription may produce persistent inhibition of DHBV replication. This study involved multiple reactions and reactants, such as 1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3COA of Formula: C10H13FN2O5).
1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione (cas: 69256-17-3) belongs to pyrimidine derivatives. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.COA of Formula: C10H13FN2O5
69256-17-3;1-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;The future of 69256-17-3;New trend of C10H13FN2O5;function of 69256-17-3