A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C26H32F2N6O4S, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 274693-26-4, Name is 2-(((3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol, molecular formula is C26H32F2N6O4S. In an article, author is Maligres, Peter E.,once mentioned of 274693-26-4.
Synthesis of Fused Oxepane HIV Integrase Inhibitor MK-1376
Controlling the absolute and relative stereochemistry of a seven-membered oxepane in the formation of HIV integrase inhibitor MK-1376 was accomplished through a strategy involving the use of asymmetric allylation and stereoconvergent, substrate-directed installation of an amine fragment. Surprising reactivity was demonstrated during the asymmetric allylation in which the allyl-pyrimidone product was formed reversibly. The stereoconvergent amine addition was accomplished through an elimination/addition sequence involving a quinone methide reactive intermediate, and nucleophilic trapping of the reactive quinone methide intermediate with methylamine. This novel approach delivered MK-1376, offering 100-fold greater productivity and 50-fold less waste than the initial synthetic chemistry route.
If you¡¯re interested in learning more about 274693-26-4. The above is the message from the blog manager. Formula: C26H32F2N6O4S.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia