As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1013916-37-4, name is 2-Chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one, molecular formula is C13H14ClN3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C13H14ClN3O
Add to dry and clean 2000ml reaction bottle8-cyclopentyl-5-methyl-2-chloro-8H-pyrido[2,3-d]pyrimidinePyridin-7-one (Formula 7) 60g, dissolved in 600g of dichloromethane,Add 90 g of sodium acetate and add 6.0 g of acetic acid.Add 100.0 g of bromine at 0-20 ,After the addition is completed,Stirring reaction for 5 hours,After TLC monitors the reaction of the raw materials,An aqueous solution of 15% sodium hydrogen sulfite in an amount of 800 g was added dropwise.Until the reddish brown bromine was completely destroyed,Stir, dispense,The organic layer is washed twice with water.Wash once again with saturated brine.Distilled under reduced pressure until no flow,Beating with ethanol-water (300g 300g) for 2h,Filtering,The target compound was obtained 65.7g,The yield is 84.28%.The purity of 99.5% of the compound of formula 9 is 0.07%.The compound of formula 10 is present in an amount of 0.01%.
With the rapid development of chemical substances, we look forward to future research findings about 1013916-37-4.
Reference:
Patent; Guang’an Kaite Pharmaceutical Co., Ltd.; Zhang Yaochun; Zhou Fuwei; Liu Xinjun; Zuo Xiaoyong; Zhou Xudong; (11 pag.)CN109320511; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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