Electric Literature of 1032452-86-0, Adding some certain compound to certain chemical reactions, such as: 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole,molecular formula is C13H10ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1032452-86-0.
c-1 (48 mg, 1.2 eq) was dissolved in isopropanol 5 mL,Then add p-toluenesulfonic acid (56 mg, 2 eq),J-6 (60 mg, 1 eq) was charged with nitrogen and reacted at 60 C, and the reaction was confirmed by TLC.Add sodium hydrogencarbonate to the reaction solution, adjust the pH to 10, and extract.Wash twice with dichloromethane and combine the organic phases.Drying under reduced pressure and separation by column chromatography to give compound 6,The yield of 30 mg was 48%.
According to the analysis of related databases, 1032452-86-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Liaoning University; Chen Ye; Ding Shi; Liu Ju; Ji Jingchao; Hao Xuechen; Liu Yutong; Li Jie; Zhang Mingjuan; Gong Yilin; (29 pag.)CN110283162; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia