Introduction of a new synthetic route about 10397-13-4

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10397-13-4, its application will become more common.

Synthetic Route of 10397-13-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 10397-13-4 as follows.

To a rubber-septum-capped vial containing 4, 6-dichloro-2-morpholinopyrimidine (0. 2 M in dioxane, 0. 25 mL) and L-PYRIDIN-2-YL-PIPERAZINE (0. 2 M in dioxane, 0. 28 mL) add aqueous K3P04 (0. 5 M, 0. 125 mL). Heat the mixture at 90C for 24 hours. Cool the mixture and concentrate under reduced pressure. Partition between ethyl acetate and water, dry (NA2S04) the organic layer and concentrate under reduced pressure. Filter the crude product through a pad of silica gel (1 : 1 ethyl acetate/hexanes) and remove the solvent under reduced pressure to give the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10397-13-4, its application will become more common.

Reference:
Patent; NEUROGEN CORPORATION; WO2005/7646; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia