137234-74-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 137234-74-3, name is 4-Chloro-6-ethyl-5-fluoropyrimidine. A new synthetic method of this compound is introduced below.
Comparative Example: Reformatsky reaction of 4-(1-bromoethyl)-5-fluoro-6-(1-methyl-1H-tetrazol-5-yl-sulfanyl)pyrimidine; Step 1: Preparation of 4-ethyl-5-fluoro-6-(1-methyl-1H-tetrazol-5-yl-sulfanyl)pyrimidine; A mixed solution of 14.5g of 5-mercapto-1-methyltetrazole and 200mL of tetrahydrofuran was cooled to 5 and 3.3g of sodium hydride was added thereto, followed by stirring for 10 minutes. After being stirred at 25 for 30 minutes, the mixed solution was cooled to 5. 20g of 4-chloro-6-ethyl-5-fluoropyrimidine was added dropwise thereto at a temperature of below 20 over 15 minutes, followed by elevation to 25 and stirring for 30 minutes. The resulting mixture was concentrated under reduced pressure and diluted with 300mL of ethyl acetate. The organic layer was successively washed with 200mL of a saturated ammonium chloride solution and 200mL of purified water. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The concentrate was crystallized from 30mL of isopropanol and 30mL of hexane, filtered and dried to afford 19g (yield: 63.4%) of a pale yellow compound. 1H-NMR (200MHz, CDCl3) delta (ppm): 8.52 (s,1H), 4.11 (s,3H), 2.86 (q,2H), 1.32 (t,3H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 137234-74-3, 4-Chloro-6-ethyl-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Boryung Pharmaceutical Co., Ltd; EP2444398; (2012); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia