Introduction of a new synthetic route about 1450-85-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1450-85-7, 2-Mercaptopyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1450-85-7, name is 2-Mercaptopyrimidine, molecular formula is C4H4N2S, molecular weight is 112.15, as common compound, the synthetic route is as follows.Computed Properties of C4H4N2S

General procedure: To an orange suspension of [Pd2(p-mazb)2Cl2] (0.025 g, 0.035 mmol) in dichloro-methane (5mL), pyridine-2-thione (0.008 g, 0.072 mmol) was added in presence of Et3N base (0.5 mL). The color of the reaction mixture became dark reddish brown and was stirred for 5-6 h. The solution was filtered off and added toluene (1 mL) and left to evaporate slowly. The dark reddish brown crystalline compound was obtained along with the formation of Et3NH+Cl- after a period of 4-5 days. Crystalline compound formed was recrystallized from dichloromethane and methanol. The dark reddish brown crystals were obtained after a period of 4-5 days. (Yield 0.021 g, 68%). .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1450-85-7, 2-Mercaptopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Lobana, Tarlok S.; Sandhu, Amanpreet K.; Kaur, Amanpreet; Jasinski, Jerry P.; Journal of Organometallic Chemistry; vol. 751; (2014); p. 519 – 524;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia