Synthetic Route of 171887-03-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 171887-03-9 as follows.
[0374] To a solution of 5 (20 g, 53 mmol) in n-BuOH (300 mL) was added DIPEA (28 mL) and 2-amino-4,6-dichloro-5-formamidopyrimidine (13.2 g, 64 mmol). Resulting mixture was heated in a sealed vessel at 160C for 24 h. Volatiles were evaporated, column chromatography (AcOEt in toluene 20-100%) afforded title compound (21 g, 75%) as a light yellow solid: 1H NMR (401 MHz, DMSO-d6) d 8.25 (s, 1H), 6.81 (s, 2H), 4.87 (t, J = 5.3 Hz, 1H), 4.74 (q, J = 9.5 Hz, 1H), 4.49 (dd, J = 9.6, 4.2 Hz, 1H), 4.01 (d, J = 4.1 Hz, 1H), 3.57 (ddd, J = 11.0, 8.0, 5.2 Hz, 1H), 3.49 (dt, J = 11.0, 5.6 Hz, 1H), 2.27 (dt, J = 13.4, 9.7 Hz, 1H), 2.11- 2.01 (m, 1H), 1.76 (ddd, J = 14.0, 9.5, 5.2 Hz, 1H), 0.91 (s, 9H), 0.65 (s, 9H), 0.11 (s, 3H), 0.08 (s, 3H), -0.16 (s, 3H), -0.51 (s, 3H); 13C NMR (101 MHz, DMSO-d6) d 159.56, 154.42, 149.50, 142.87, 124.09, 75.99, 74.55, 63.22, 58.88, 46.12, 27.71, 26.05, 25.66, 18.01, 17.61, -4.31, -4.42, -5.54; ESI MS m/z (%): 528.3 (100) [M+H], 550.2 (49) [M+Na]; HRMS ESI (C23H43O3N5ClSi2) calculated: 528.25875; found: 528.25868.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,171887-03-9, its application will become more common.
Reference:
Patent; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ASCR, V.V.I.; BIRKUS, Gabriel; DEJMEK, Milan; NENCKA, Radim; PAV, Ondrej; SALA, Michal; (206 pag.)WO2019/211799; (2019); A1;,
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