Reference of 19752-61-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19752-61-5, name is 5-Bromo-2,4-di-tert-butoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
The starting material 2,4-di-tert.butoxy-5-(3′-furyl)pyrimidine was prepared as follows: A 250 ml flask equipped with condenser, magnetic stirrer and nitrogen inlet was charged with 7.3 g (0.024 mole) of 5-bromo-2,4-di-tert-butoxypyrimidine, 0.75 mmol of tetrakis(triphenylphosphine)palladium (0) and 80 ml of 1,2-dimethoxyethane. After stirring for 10 min 3.0 g (0.027 mole) of 3-furanboronic acid was added, immediately followed by 60 ml of 1M sodium carbonate solution. The reaction mixture was refluxed for 4 hours with vigorous stirring under nitrogen. After cooling to room temperature, the traces of catalyst were filtered off, the organic solvent was evaporated under reduced pressure and the residue diluted with water and extracted with three 50 ml portions of ether. The combined etheral phases were washed with water, saturated sodium chloride solution and dried over magnesium sulphate. The ether was evaporated and the residue was purified by flash chromatography using hexane-ethyl acetate (4:1) as eluent, yielding 4.1 g (59%) of the title compound as an oil. Anal. Found C 66.5, H 7.68, N 9.64, O 17.0. Calc. for C16 H22 N2 O3 (290.4) C 66.2, H 7.64, N 9.65, O 16.5.
According to the analysis of related databases, 19752-61-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Medivir AB; US5440040; (1995); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia