Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide. A new synthetic method of this compound is introduced below., Computed Properties of C12H12Cl2N3OP
Add compound 8a to a 25 mL single-mouth bottle with magnetic stirrer and condenser(760 mg, 3.21 mmol), compound 5a (1.01 g, 3.21 mmol)And ethylene glycol monomethyl ether (10mL), stir and dissolve, add hydrogen chloride isopropanol solution(4.82mmol, 0.96mL, 5M),The temperature was raised to 120 C under a nitrogen atmosphere and stirred to react overnight. Cool to room temperature,Add water (10 mL) and saturated sodium bicarbonate (5 mL) and dichloromethane (15 mL×3)The organic phase was combined, washed with saturated brine and dried over anhydrous sodium sulfate.Filtration, concentration, and residue over silica gel to give a white solid600 mg, the yield was 36.1%.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide.
Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (49 pag.)CN109851638; (2019); A;,
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