Reference of 36315-01-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. A new synthetic method of this compound is introduced below.
In a 1 OOO mL reaction flask, 100 g of 2-sulfonyl chloride-N, N-dimethylnicotinamide (0.40 mol) 40 g of sodium cyanate (0.62 mol), 101 g of triethylamine (1.00 mol) and 125 g of acetonitrile were charged and the mixture was stirred at 25 ± 5 C for isocyanating. After 5 h, 75 g of 2-amino-4,6-dimethoxypyrimidine (0.48 mol) was added to the reaction flask and stirred for 1 h at ambient temperature (0 to 40 C). After the completion of the condensation reaction, 500 g of deionized water (about 1.5 h) was added dropwise to the reaction bottle. After dropping, the pH was adjusted to 1.0 with hydrochloric acid, After drying, 157.8 g of nicosulfuron were obtained in a yield of 92.1% and a purity of 95.7%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu agricultural hormone Engineering Technology Research Center Co., Ltd.; Jiangsu Hormone Research Institute Co., Ltd; Sun, Yong Hui; kong, Fan Lei; Shi, yueping; Gao, Jian Hong; Zhang, Yuan yuan; Cao, Wei; (5 pag.)CN103524493; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia