With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine, molecular formula is C6H9N3O2, molecular weight is 155.16, as common compound, the synthetic route is as follows.Computed Properties of C6H9N3O2
To 50 ml pear-shaped flask add 155 mg (1 mmol) of 2 – amino – 4, 6 – dimethoxy pyrimidine solid and 8 ml of dried DMF, stirring to dissolve adding 2 g water-free K2CO3, Stirring under the room temperature condition 0.5 h, then to slow added in the reaction system of 270 mg (1 mmol) of 5 – bromo valeric acid O-methyl ester, stir at room temperature overnight TLC monitoring to the reaction is complete. After the reaction is finished adding 40 ml of water, then 2 × 50 ml ethyl acetate, the combined organic phase sequentially for 2 × 50 ml of 1 N HCl solution, 2 × 50 ml of saturated sodium chloride solution. The organic phase after drying over anhydrous sodium sulfate the solvent is removed by reduced pressure distillation after purification on silica gel, ethyl acetate/petroleum ether (v/v, 4/1) elution, to obtain light yellow oily liquid, yield 72%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Northwest A&F University; Ji Zhiqin; Wei Shaopeng; (12 pag.)CN107857735; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia