Adding a certain compound to certain chemical reactions, such as: 3073-77-6, 2-Amino-5-nitropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3073-77-6, blongs to pyrimidines compound. Computed Properties of C4H4N4O2
Example 51. 4-(5-Nitropyrimidin-2-ylammo)-iV-(2-hydroxyethyl)-iV- isopropylbenzamide (37); [0192] A mixture of 5-nitro-pyrimidin-2-ylamine (142 nig, 1.0 mniol), bromide intermediate 36 described in Example 50 (285 mg, 1.0 mmol), Cs2CO3 (1.4 g, 4.3 rnrnol), Xantphos (114 mg, 0.2 mmol), and Pd2(dba)3 (91 mg, 0.1 mmol) in dioxane (20 mL) was purged with argon for 5 min, and the ssuspension was heated to reflux for 2.5 hours under argon. Dioxane was removed in vacuo, and the crude mixture was adsorbed onto silica gel and purified using an Isco flash chromatography system (0% to 10% Methanol with 1% NH4OH in DCM) to afford a crude tan solid (357 mg, quant.).[0193] 1H NMR (DMSO-d6) delta 1.10 (bs, 6H), 3.54 (bs, 2H), 4.74 (bs, IH), 7.36 (d, J= 8.5 Hz, 2H), 7.82 (d, J= 8.5 Hz, 2H), 9.26 (s, 2H), 10.99 (s, IH). MS (ES+): m/z = 346 (M+H)+. LC retention time: 2.18 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3073-77-6, its application will become more common.
Reference:
Patent; TARGEGEN, INC.; WO2006/101977; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia