Introduction of a new synthetic route about 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4214-85-1, 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4214-85-1, name is 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, molecular formula is C5H6N4O3, molecular weight is 170.13, as common compound, the synthetic route is as follows.Formula: C5H6N4O3

(E)-iV.H/V-Dimethyl-Lambdarf-(4-methyl-5-nitro-6-oxo-l,6-dihydropyrimidin-2- yl)formimidamideTo a suspension of 2-Amino-6-methyl-5-nitropyrimidin-4(3H)-one (54.8 g, 0.32 mol) in CH2Cl2 (461 mL) was added DMF-dimethylacetal (103.1 mL, 0.77 mol) and stirred at room temperature for 1.5 h. The reaction mixture was filtered, washed with CH2Cl2, and used for the next step without further purification (31.9 g, 44% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4214-85-1, 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, and friends who are interested can also refer to it.

Reference:
Patent; VALEANT RESEARCH & DEVELOPMENT; WO2006/122003; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia