Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22536-66-9, name is 2-Chloropyrimidine-4-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloropyrimidine-4-carboxamide
A mixture of 2-[[2-am ino-6-(3-chloro-2-methyl-phenyl)pyrimidin-4-yl]am inojethanol (intermediate 19), 2-chloropyrimidine-4-carboxamide (1.5 equiv.) and 052003 (2.0 equiv.) in DMSO was heated in a sealed tube at 90 00 for 16 h. After coolingmethanol was added followed by filtration and purification by preparative LC to give the title compound. LCMS [M+H] 400. 1H NMR (400 MHz, METHANOL-d4) oe ppm 8.78 (d, J=5.i Hz, 1 H), 7.68 (d, J=5.i Hz, 1 H), 7.40 (dd, J=7.4, 1.7 Hz, 1 H), 7.16 – 7.24 (m, 2 H), 5.82 (br. s., 1 H), 4.67 (t, J=5.5 Hz, 2 H), 3.73 – 3.92 (m, 2 H), 2.31 (5, 3 H).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 22536-66-9, 2-Chloropyrimidine-4-carboxamide.
Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; JACQUES, Sylvain; HOMAN, Evert; HELLEDAY, Thomas; WO2015/187088; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia