Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37972-24-0, name is 2-Ethynylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H4N2
To a solution of 226(100mg, 0.282mnmoi) and 4(58.8mg, 0565mmo1) in 2OmnL of Et3N was added Pd(PPh3)2C12 (9.91mg, 0.Ol4mmol) and CuT (5.38mg, 0.O28mmol). The mixture was protected with N2 atmosphere, then was heated at 70°C for 4 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was thenconcentrated in vacuo. The crude product was purified by Prep-HPLC to give the target productCompound 93(20mg, yield: 21.44percent).LCMS: m/z 33 1 (M+H1H NMR (400 MHz, CDCI3): oe 8.76 (d, J 5.2 Hz, 2H), 8.21 (d, J= 0.8 Hz, IH), 7.98 (s, IH),773 (d, J == 9.2 Hz, 2H), 7.36-7.34 (m, 2H), 726 (d, J= 9.6 Hz, 11-I).
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Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia