As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23002-51-9, name is 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C5H3ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine
Example 74 : N-( 1 -Methyl- 1 H-pyrazo 1-4-yl)- 1 -phenyl- 1 H-pyrazo lo [3 ,4-d]pyrimidin-6-amine Step (i)A suspension of 6-chloro-lH-pyrazolo[3,4-d]pyrimidine (lOOmg, 0.65mmol), benzene boronic acid (1.5eq), copper acetate (2eq) and pyridine (2eq) in dichloromethane (2mL) was heated in the microwave at 80C for 15min. After cooling to rt, the mixture was filtered and the resulting filtrate concentrated to give 6-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine as a green oil (138mg, 92%) which was used without further purification in the next step.
With the rapid development of chemical substances, we look forward to future research findings about 23002-51-9.
Reference:
Patent; CELLZOME LIMITED; RAMSDEN, Nigel; HARRISON, Richard John; OXENFORD, Sally; BELL, Kathryn; PITON, Nelly; DAGOSTIN, Claudio; BOUSSARD, Cyrille; RATCLIFFE, Andrew; WO2011/48082; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia