Reference of 3177-24-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3177-24-0, name is 2,4-Dichloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows.
PREPARATION 972-Amino-4-chloropyrimidine-5-carbonitrileTo a solution of 2,4-dichloropyrimidine-5-carbonitrile (600mg, 3.45mmol) in dioxane (20ml) was added a 0.5M solution of NH3 in dioxane (20ml, 10 mmol) and the mixture stirred at room temperature for 4h. A mixture of two isomers were obtained and separated by column chromatography using a mixture of hexane/ethyl acetate (from 0percent to 45percent of ethyl acetate). The title compound (304mg, 56percent yield) was found to be the less polar isomer.LRMS (m/z): 153 (M-1 )\
According to the analysis of related databases, 3177-24-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ALMIRALL, S.A.; BERNAL ANCHUELA, Francisco Javier; CARRASCAL RIERA, Marta; CATURLA JAVALOYES, Juan Francisco; GRACIA FERRER, Jordi; MATASSA, Victor Giulio; TERRICABRAS BELART, Emma; TALTAVULL MOLL, Joan; ERRA SOLA, Montserrat; WO2012/146666; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
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