Reference of 1780-40-1 , The common heterocyclic compound, 1780-40-1, name is 2,4,5,6-Tetrachloropyrimidine, molecular formula is C4Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 2,4,5,6-tetrachloropyrimidine (5 g, 22.9 mmol) in THF (50 mL) was added 1N NaOH (31 mL, 31.2 mmol) dropwise, and the mixture was stirred overnight at RT. The solution was acidified with 1N HCl and extracted with DCM (3x). The organics were combined, dried, and concentrated in vacuo. The solids were slurried in Et2O for 30 min at RT, filtered, washed with Et2O, and dried to give 3.0 g (66%) of the title compound. [M+H] Calc?d for C4HCl3N2O, 201; Found, 201.
The synthetic route of 1780-40-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CELGENE CORPORATION; XU, Jiangchun; CHO, Robert; NGUYEN, Aaron; (297 pag.)WO2018/31658; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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