Synthetic Route of 26032-72-4 ,Some common heterocyclic compound, 26032-72-4, molecular formula is C10H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
[00240] To a solution of 2,4-dichloro-6-phenylpyrimidine (1.52 g, 6.7 mmol) and (¡À)-trans-methyl 3-aminobicyclo[2.2.2]octane-2-carboxylate (1.84 g, 10.0 mmol) inN,N-dimethylformamide (10 mL) was added potassium carbonate (0.92 g, 6.7 mmol). The mixture was stirred at rt overnight. After the reaction was completed, the mixture was diluted with H20 (50 mL), and the resulting mixture mixture was extracted with ethyl acetate (40 mL x3). The combined organic layers were washed with saturated brine (50 mL), dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (n-hexane/EtOAc (v/v) = 20/1 – 10/1) to give the title compound as a white solid (1.65 g, 66%).MS (ESI, pos.ion) m/z: 372.2 [M+H]+1H NMR (400 MHz, CDC13) (ppm): 8.04-7.91 (m, 2H), 7.5 1-7.41 (m, 3H), 6.78 (s, 1H), 5.41 (s, 1H), 4.32 (s, 1H), 3.73 (s, 3H), 2.38 (d, J= 5.1 Hz, 1H), 2.07 (s, 1H), 1.86 (m, 1H), 1.73 (m, 1H),1.70-1.60 (m, 4H), 1.57 (m, 2H), 1.5 1-1.41 (m, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26032-72-4, 2,4-Dichloro-6-phenylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; REN, Qingyun; TANG, Changhua; LIN, Xiaohong; YIN, Junjun; YI, Kai; (270 pag.)WO2017/97234; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia