Introduction of a new synthetic route about 32779-36-5

The synthetic route of 32779-36-5 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 32779-36-5, name is 5-Bromo-2-chloropyrimidine, the common compound, a new synthetic route is introduced below. 32779-36-5

Preparation B: N- j5-(4-bromophenyl)-6- j2- j(5-bromo-2-pyrimidinyl)oxyj ethoxyj – 4-pyrimidinylj -N?- propylsulfamide (macitentan):N-(5 -(4-bromophenyl)-6-(2-hydroxyethoxy)pyrimidin-4-yl)propane- 1 -sulfamide (200 g; 0.46 mol; see Example 2 or 3) and 5-bromo-2-chloropyrimidine (117 g; 0.60 mol; 1.3 eq) were dissolved in toluene (3 L) and DMF (400 mL). The reaction mixture was warmed up to 50¡ãC and toluene (approx. 400 mL) was distilled our under reduced pressure. The mixture was cooled to 0 ¡ãC and tBuOK (156 g, 3 eq, 1.38 mol) was added portionwise. It was stirred at 20 ¡ãC for 1 h. Water (1 L) was added and the pH of the solution was adjusted to 3-5 using 33percent aq. HC1. The mixture was heated to 50¡ãC and the layers were separated. The org. phase was treated with charcoal at 50¡ãC and filtered over Celite. The filter cake was rinsed with toluene. At 50¡ãC, water (1 L) was added to the org. layer. The layers were separated. The org. layer was concentrated under reduced pressure to a total volume of 1 L and cooled to 0¡ãC. The solid obtained was filtered off It was rinsed with toluene and MeOH. The crude material was suspended in EA (1 L) and heated to 50¡ãC. 300 mL of EA were distilled out and MeOH (400 mL) was added. The suspension was cooled down to 0¡ãC. The solid was filtered off, rinsed with MeOH and dried under reduced pressure to afford the title compound as a white solid (225 g; 83percent yield).

The synthetic route of 32779-36-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; ABELE, Stefan; FUNEL, Jacques-Alexis; SCHINDELHOLZ, Ivan; WO2014/155304; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia