Reference of 3435-25-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3435-25-4, name is 4-Chloro-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
A solution of (S)isopropyl 2-(tert-butoxy)-2-(4-(8-fluorochroman-6-yl)-2,6-dimethyl-5 -(1,2,3,4- tetrahydroi soquinolin-6-yl)pyridin-3 -yl)acetate, 2 HC1 (0.015 g, 0.024 mmol), potassium carbonate (0.03 g, 0.217 mmol) and 4-chloro-6-methylpyrimidine (4.57 mg, 0.036 mmol) in dioxane (0.5 mL) was stirred at 100 C for 20 h in a sealed vial, and then treated withsodium hydroxide (0.02 g, 0.500 mmol) in EtOH (lml) at 85 C for 2 h. Then, cooled and purified by prep HPLC to afford (S)-2-(tert-butoxy)-2-(4-(8-fluorochroman-6-yl)-2,6- dimethyl-5-(2-(6-methylpyrimidin-4-yl)- 1,2,3 ,4-tetrahydroisoquinolin-6-yl)pyridin-3 – yl)acetic acid (0.0082 g, 0.013 mmol, 56.7% yield). LCMS (M+H) = 611.2.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3435-25-4, 4-Chloro-6-methylpyrimidine.
Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; TU, Yong; (133 pag.)WO2017/29631; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia