The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 374930-88-8, name is tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C13H19BrN4O2
To a stirred solution of tert-butyl-4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate (15.0 g, 43.7 mmol) in 1,4-dioxane (50 mL), HCI in dioxane (150 mL, 10V, 4N) was added at 0 C and stirred at rt for 4 h. The resulting white precipitate was filtered and was washed with Et2O (25 mL), EtOAc (2 x 20 mL) to afford the title product. Yield: 98.2% (12.0 g, off white solid). 1H NMR (400 MHz, DMSO-d6): delta 9.40 (br s, 2H), 8.54 (s, 2H), 3.93 (t, J = 4.8 Hz, 4H), 3.13 (br s, 4H). LCMS: (Method A) 244.9 (M -35), Rt. 1.71 min, 99.8 % (Max).
With the rapid development of chemical substances, we look forward to future research findings about 374930-88-8.
Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh, S.; GIRI, Awadut Gajendra; (247 pag.)WO2017/144639; (2017); A1;,
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