Synthetic Route of 100644-65-3 ,Some common heterocyclic compound, 100644-65-3, molecular formula is C5H4ClN5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 192. 4-Chloro-1-(4-chloro-3,5-diemthyl-pyridin-2-ylmethyl)-1H- pyrazolo [3, 4-D] PYRIMIDIN-6-YLAMINE A mixture OF 4-CHLORO-LH-PYRAZOLO [3, 4-D] PYRIMIDIN-6-YLAMINE (158 mg), crude 4-chloro-2-chloromethyl-3,5-dimethyl-pyridine (204 mg), CS2C03 (660 mg) and DMF was heated to 80 C for 1.5 h, diluted with EtOAc and washed with water. The crude material was concentrated and suspended in MEOH/DCM. Filtration gave a 2: 1 mixture of regioisomers which was further purified by preparative silica gel plate (EtOAc 100%). The major (less polar) isomer corresponded to the title compound. R. t. 5.45 MIN. H- NMR (CDC13) 8 8.22 (s, 1H), 7.90 (s, 1H), 5.57 (s, 2H), 5.28 (s, 2H), 2.43 (s, 3H), 2.31 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100644-65-3, its application will become more common.
Reference:
Patent; CONFORMA THERAPEUTICS CORPORATION; WO2005/28434; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia