Application of 16097-63-5 ,Some common heterocyclic compound, 16097-63-5, molecular formula is C6H4ClF3N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution [OF 2-THIOMETHYL-4-CHLORO-6-TRIFLUOROMETHYLPYRIMIDINE] (1.9996 g, 8.75 mmol) in [MEOH] (50 mL) was added morpholine (1.5 mL, 17.2 [MMOL).] The solution was stirred overnight, concentrated in vacuo, and the resulting white solid was collected by vacuum filtration and washed with water. To a solution of the solid in [CH2C12] (50 mL) was added m- chloroperbenzoic acid (4.53 g, 26.3 mmol), and the resulting solution was stirred for 2 h at which time it was observed to be a white suspension. The solvent was removed in vacuo, and then [MEOH] (50 mL) was added followed by hydrazine monohydrate (3.0 mL, 61.8 mmol). The solution was stirred for 16 h, and was then concentrated to about one-half volume in vacuo. Water (100 mL) was then added to the resulting suspension, and the observed white solid was collected by vacuum filtration. This material was then washed with water and dried in vacuo to afford 1.7193 g of the title compound [(75%)] as a white solid. MH+ 264.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16097-63-5, its application will become more common.
Reference:
Patent; Smithkline Beecham corporation; WO2003/101442; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia