As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 67434-65-5, name is 4-Chloro-5,6-dimethylpyrimidine, molecular formula is C6H7ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 4-Chloro-5,6-dimethylpyrimidine
EXAMPLE 5 4-(4-Isopropylanilino)-5,6-dimethylpyrimidine (Compound No. 47) To 3.6 g (0.025 mole) of 4-chloro-5,6-dimethylpyrimidine were added 3.4 g (0.025 mole) of p-isopropylaniline; the mixture was then heated at 100-150 C. for about 3 minutes. The reaction mixture quickly became a solution and soon produced a precipitate, which was separated and then made alkaline by the addition of 50 ml of a dilute aqueous solution of sodium hydroxide. The mixture was then extracted with ethyl acetate and the extract was washed, in turn, with water and with a saturated aqueous solution of sodium chloride. It was then dried over anhydrous sodium sulphate and then the ethyl acetate was distilled off under reduced pressure, to give crystals, which, on recrystallisation froma 3:1 by volume mixture of benzene and hexane, gave 1.4 g (yield 23%) of the desired product in the form of very fine colourless needles melting at132-133 C. Elemental analysis: Calculated for C15 H19 N3: C, 74.69%; H, 7.88%; N, 17.43%. Found: C, 75.00%; H, 7.90%; N, 17.70%.
With the rapid development of chemical substances, we look forward to future research findings about 67434-65-5.
Reference:
Patent; Sankyo Company, Limited; Ube Industries Limited; US4450162; (1984); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia