Introduction of a new synthetic route about 4-Chlorothieno[2,3-d]pyrimidine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14080-59-2, 4-Chlorothieno[2,3-d]pyrimidine.

Reference of 14080-59-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14080-59-2, name is 4-Chlorothieno[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Compound 208d: 3-[2-(Thieno[2,3-d]pyrimidin-4-ylamino)-phenoxy]- pyrrolidine-1-carboxylic acid tert-butyl ester: A suspension of 3-(2-nitro-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester (1.0g, 3.6 mmol, 1.0 eq), 4-chloro-thieno[2,3d]pyrimidine (0.61 g, 3.6 mmol, 1.0 eq) and DIPEA (0.74 g, 5.76 mmol, 1 ,6 eq) in IPA (8 ml) was heated at 1200C for 5 days. The reaction was allowed to cool to room temperature and the solvent removed in vacuo. The resultant residue was purified by column chromatography using ethyl acetate/ cyclohexane [1 :1] as eluent to give the title compound (0.64 g, 1.56 mmol, 43%). 1H NMR indicates desired compound in ca. 95% purity.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14080-59-2, 4-Chlorothieno[2,3-d]pyrimidine.

Reference:
Patent; DEVELOGEN AKTIENGESELLSCHAFT; WO2006/136402; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia