In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4270-27-3, name is 6-Chloropyrimidine-2,4(1H,3H)-dione, the common compound, a new synthetic route is introduced below. Recommanded Product: 4270-27-3
Into a dry Schlenk reaction tube was added 6-chloropyrimidine-2,4 (1H, 3H) -dione (0.29 g, 2.0 mmol), pyridin-2-ylboronic acid (0.3 g, 2.2 mmol), Tetrakis (triphenylphosphine) palladium (29 mL, 0.025 mmol) and K2CO3 (0.33 g, 2.4 mmol) were added , then 1,4-dioxane (10 mL), water (2 mL) was added under nitrogen atmosphere for 4 h at 45 C. After completion of the reaction, the solvent was removed under reduced pressure, and the residue was dissolved in ethyl acetate , then separated by silica gel column chromatography and eluting with petroleum ether / ethyl acetate 20: 1 to give a pale yellow solid 6- (pyridin-2-yl)pyrimidine-2,4 (1H,3H)-dione. Its 0.28 g of a pale yellow solid, 98% purity, yield 74%.
The synthetic route of 4270-27-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mudanjiang Medical School; Song Jing; Sun Zhiguo; Han Guangyu; Li Hailin; Wang Wei; (15 pag.)CN106946851; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia