4595-59-9 , The common heterocyclic compound, 4595-59-9, name is 5-Bromopyrimidine, molecular formula is C4H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Benzyl bromide (1 mmol), alkyl halide (1.1 mmol), thiourea (1.2 mmol), and K2CO3(3 mmol) were added to 5 mL of DMF at 100 C. The reaction was stopped after the consumptionof the benzyl bromide, which was monitored by gas chromatography (GC). Then, the reaction mixture was diluted with de-ionized water and extracted with CH2Cl2. Thecombined organic extracts were dried over anhydrous MgSO4, filtered, and concentrated byrotary evaporation to generate a crude product. Purification by silica gel chromatographyeluting with n-hexane afforded pure thioethers.
The synthetic route of 4595-59-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lu, Xiaogang; Wang, Hongmei; Gao, Runli; Pei, Chengxin; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 1; (2015); p. 45 – 52;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia