Adding a certain compound to certain chemical reactions, such as: 46155-89-9, 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 46155-89-9, blongs to pyrimidines compound. Recommanded Product: 46155-89-9
A solution of 1 g (5.58 mmol)of compound 1a in 5 mL of concentrated sulfuric acid was cooled to 2-5C, and a mixture of 0.37 mL(5.58 mmol) of nitric acid (d = 1.41 g/cm3) and 2 mL of concentrated sulfuric acid was added dropwise with vigorous stirring and cooling. The mixture was stirred for 1 h and poured onto 20 g of ice. After 30 min, the precipitate was filtered off and washed with 10 mL of water. Yield 0.77 g (62%, assuming formation of mononitro derivatives). According to the 1H NMR data, the product was a mixture of 6- and 7-nitro derivatives ata ratio of 7 : 93. It was recrystallized from 55 mL of ethanol to isolate 0.47 g (38%) of 7-nitro isomer 2a,mp 272-273C. IR spectrum, nu, cm-1: 3150 m (NH),1710 s, 1680 s (C=O), 1575 s, 1390 s (NO2). 1H NMRspectrum (DMSO-d6), delta, ppm: 3.25 s (3H, 1-CH3),3.58 s (3H, 3-CH3), 8.27 d (1H, 6-H, J = 3.47 Hz),13.55 br.s (1H, NH). Found, %: C 42.73; H 3.70;N 24.88. C8H8N4O4. Calculated, %: C 42.86; H 3.60;N 24.99.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,46155-89-9, 1,3-Dimethyl-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, and friends who are interested can also refer to it.
Reference:
Article; Tkachenko, Yu. N.; Popov; Pozharskii; Borodkin; Levchenkov; Russian Journal of Organic Chemistry; vol. 53; 10; (2017); p. 1564 – 1572; Zh. Org. Khim.; vol. 53; 10; (2017); p. 1536 – 1543,8;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia