Introduction of a new synthetic route about 5-Chloropyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17180-94-8, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 17180-94-8, 5-Chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 17180-94-8, blongs to pyrimidines compound. Safety of 5-Chloropyrimidine

To a solution of 5-chloropyrimidine (5 mmol) and Ni(dppf)Cl2 (0.25 mmol) in ether (30 mL) was added MeMgBr (6 mmol, 1M in THF) dropwise under nitrogen atmosphere and the resulting mixture was refluxed overnight. After cooling to rt, water (20 mL) was added and the mixture was extracted with ether (3 x 35 mL). The combined organic layers were washed with brine, dried over anhydrous Na2S04. After filtration and concentration, the crude product was purified by column chromatography to give the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17180-94-8, its application will become more common.

Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; CAMPBELL, John, Emmerson; CAMPBELL, Una; HANANIA, Taleen, G.; SHAO, Liming; WO2013/119895; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia