Introduction of a new synthetic route about 5194-32-1

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5194-32-1, its application will become more common.

Application of 5194-32-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5194-32-1 as follows.

General procedure: General CoulinQ Procedure 5 POd3 (3 eq.) was added to a stirred solution of carboxylic acid A (1 .0 eq.) and amine B (1 .0 eq.) in pyridine (25 mL) at 0 C. The reaction mixturewas stirred for I h at RT. The reaction mixture was then filtered and the filtrate was diluted with ethyl acetate (100 mL) then washed with water and brine (100 mL each). The organic layer was dried over Na2SO4 and concentrated under reduced pressure to obtain the crude product, which was then purified by preparative H PLC.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5194-32-1, its application will become more common.

Reference:
Patent; FROST BIOLOGIC, INC.; SIDDIQUI-JAIN, Adam; WO2015/127284; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia